PDF MicroRNAs in Development (Current Topics in Developmental Biology)

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Hammond said his lab also expects to publish an miRNA finding related to a disease pathway shortly. Are Nanobacteria Making Us Ill? All Bio Systems Are Go. Building Blocks for a Tiny World. View Comments.

Current Topics in Developmental Biology, Volume 76 - 1st Edition

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MicroRNAs and DNA methylation as epigenetic regulators of mitosis, meiosis and spermiogenesis

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Author: Robbie Gonzalez Robbie Gonzalez. Human neoplasias, including thyroid, prostatic, cervical, colorectal, pancreatic and ovarian carcinomas, show a strong increase of HMGA1a and HMGA1b proteins. The global role of miRNA function in the heart has been addressed by conditionally inhibiting miRNA maturation in the murine heart.

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This revealed that miRNAs play an essential role during its development. Murine microRNA is a potential biomarker i. These findings were observed in ligated carotid arteries of mice to mimic the effects of d-flow. Within 24 hours, pre-existing immature miR formed mature miR suggesting that miR is flow-sensitive. Arterial ECM is mainly composed of collagen and elastin fibers, providing the structural support and recoil properties of arteries.

Consistent with these findings, inhibition of pre-miR increases expression of TIMP3 in cells, even when exposed to turbulent flow. When tested, d-flow decreased the expression of XRN1 in humans as it did in mice endothelial cells, indicating a potentially common role of XRN1 in humans.


Targeted deletion of Dicer in the FoxD1 -derived renal progenitor cells in a murine model resulted in a complex renal phenotype including expansion of nephron progenitors, fewer renin cells, smooth muscle arterioles , progressive mesangial loss and glomerular aneurysms. Using a lineage tracing approach followed by Fluorescent-activated cell sorting , miRNA profiling of the FoxD1-derived cells not only comprehensively defined the transcriptional landscape of miRNAs that are critical for vascular development, but also identified key miRNAs that are likely to modulate the renal phenotype in its absence.

Consistent with the profiling results, ectopic apoptosis was observed in the cellular derivatives of the FoxD1 derived progenitor lineage and reiterates the importance of renal stromal miRNAs in cellular homeostasis. The vital role of miRNAs in gene expression is significant to addiction , specifically alcoholism. Another class of miRNAs that regulate insulin resistance , obesity , and diabetes , is the let-7 family.

Let-7 accumulates in human tissues during the course of aging. Not only could let-7 inhibition prevent obesity and diabetes, it could also reverse and cure the condition. When the human genome project mapped its first chromosome in , it was predicted the genome would contain over , protein coding genes. However, only around 20, were eventually identified.

Hence, miRNAs play a key role in host—virus interactions and pathogenesis of viral diseases.

It is of key importance to identify the miRNA targets accurately. From Wikipedia, the free encyclopedia. Main article: RNA-induced silencing complex. Bibcode : Natur. Annual Review of Biochemistry. Annual Review of Genetics. Current Biology. Genome Research. Bibcode : Sci Annual Review of Plant Biology.

Transcriptional Switches During Development, Volume 98 Current Topics in Developmental Biology

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